目前已成功地克隆出δ、μ、κ阿片受体 ,均属Ｇ蛋白偶联受体 ,有 6 5 %同源序列 ,仅 35 %序列决定其特异性。阿片受体最大的同源区是跨膜区 (ｔｒａｎｓｍｅｍｂｒａｎｅ ,ＴＭ)和细胞内环 ,变化最大的区域在细胞外环及其氨基、羧基末端。近年来应用反义核酸技术、基因剔除、 At present, the δ, μ, κ opioid receptors have been successfully cloned, all of which are G protein-coupled receptors with 65% homologous sequences and only 35% sequences determine their specificity. The largest homology region of opioid receptors is the transmembrane (TM) and intracellular loop, the most frequently changing region being at the extracellular loop and its amino and carboxy termini. In recent years, the application of antisense nucleic acid technology, gene knockout,