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目的探讨血浆B型利钠肽原(BNP)水平对老年呼吸困难患者鉴别诊断的应用价值,为正确治疗提供依据。方法收集我院急诊科老年呼吸困难患者159例,入院时检查血浆BNP含量,并给予心脏超声检查,分别比较心源性呼吸和肺源性呼吸困难组BNP水平和左室射血分数的区别;比较心源性呼吸困难组BNP含量与左室射血分数(LVEF)的相关性。结果肺源性呼吸困难组患者BNP含量为(126.7±23.4)pg/mL,心源性呼吸困难组患者BNP含量为(946.8±125.3)pg/mL(P=0.001);相关分析显示老年心源性呼吸困难组BNP与左室射血分数呈负相关关系(r=-0.63,P<0.01)。结论血浆BNP水平检测在老年呼吸困难患者具有一定的鉴别诊断作用,能够反映患者的心功能情况。
Objective To investigate the value of plasma BNP level in the differential diagnosis of elderly patients with dyspnea and provide evidence for correct treatment. Methods A total of 159 elderly patients with dyspnea who were admitted to our emergency department were enrolled in this study. Plasma BNP levels were measured at admission and echocardiography was performed. The differences between BNP levels and left ventricular ejection fraction were compared between cardiorespiratory and pulmonary dyspnea groups. The correlation between BNP level and left ventricular ejection fraction (LVEF) in cardiogenic dyspnea group was compared. Results BNP level was 126.7 ± 23.4 pg / mL in patients with pulmonary dyspnea, and 946.8 ± 125.3 pg / mL in patients with cardiorespiratory dyspnea (P = 0.001). The correlation analysis showed that the heart rate There was a negative correlation between BNP and left ventricular ejection fraction in patients with dyspnea (r = -0.63, P <0.01). Conclusion The plasma BNP level in the elderly patients with dyspnea has a certain differential diagnosis, can reflect the patient’s cardiac function.