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应用建立的单克隆抗体ＰＣＡ_２的ＥＬＩＳＡ结合抑制法对５０名正常人，３１例经手术病理证实的胰腺癌，１７例急性胰腺炎和８例慢性胰腺炎进行检测。结果表明，单抗ＰＣＡ_２所对应的抗原（ＰＣＡ_２－Ａｇ）在胰腺癌患者血清中的平均含量显著高于正常对照组（Ｐ＜０．００１）。ＰＣＡ_２－Ａｇ诊断胰腺癌的灵敏度为７７．４％，特异性为９５．７％。ＰＣＡ_２－Ａｇ与ＣＡ１９－９、ＣＥＡ联合检测可提高胰腺癌的正确诊断率。ＰＣＡ_２－Ａｇ的检测对胰腺癌具有一定的诊断价值。
50 healthy individuals, 31 cases of pancreatic carcinoma confirmed by pathology, 17 cases of acute pancreatitis and 8 cases of chronic pancreatitis were detected by ELISA and inhibition method of monoclonal antibody PCA_2. The results showed that the average level of PCA 2 antigen (PCA 2 -Ag) in serum of patients with pancreatic cancer was significantly higher than that of the normal control group (P <0.001). The sensitivity of PCA_2-Ag in the diagnosis of pancreatic cancer was 77.4% and the specificity was 95.7%. PCA_2-Ag and CA19-9, CEA joint detection can improve the correct diagnosis of pancreatic cancer. PCA_2-Ag detection of pancreatic cancer has a certain diagnostic value.