论文部分内容阅读
目的分析连云港市新生儿先天性甲状腺功能低下症(CH)发病率及碘营养状况对CH发病率的影响。方法筛查对象为连云港市142家有助产资质的医院足月顺产新生儿共431 524名。按卫生部《新生儿疾病筛查技术规范》进行。结果该市2000年实施新生儿筛查,从431 524名新生儿中确诊212名CH(发病率1/2035),其中2007、2008年CH发病率有明显增长(1/1 385,1/1 435)。2009年CH发病率(1/2 602)恢复到2006年水平(1/2 732)。分析CH发病率上升的因素,可能是人群碘营养过量有关(1998年尿碘MUI≥300μg/L),经调整IDD防治策略,2009年儿童尿碘MUI 127.0μg/L,母亲尿碘MUI 261.1μg/L结论对于基础是碘缺乏的人群,高碘摄入会引起甲状腺疾病的增加,否定食盐碘化(USI)政策是不可取的,然而盲目补碘也是错误的。
Objective To analyze the incidence of neonatal congenital hypothyroidism (CH) and iodine nutrition status of CH in Lianyungang. Methods: The screening of 431 524 full-term newborn babies in 142 midwifery hospitals in Lianyungang City. According to the Ministry of Health “Neonatal Screening Disease Technical Code”. Results The city conducted neonatal screening in 2000 with 212 confirmed CHs (incidence 1/2035) out of 431,524 newborns, with a significant increase in CH incidence in 2007 and 2008 (1/1 385, 1/1 435). The CH incidence in 2009 (1/2 602) returned to 2006 levels (1/2 732). Analysis of CH increased incidence of factors may be related to population iodine overdose (1998 urinary iodine MUI ≥ 300μg / L), adjusted IDD prevention and treatment strategies, 2009 urinary iodine MUI 127.0μg / L, the mother urine iodine MUI 261.1μg / L Conclusions For people who are based on iodine deficiency, high iodine intake causes an increase in thyroid disease. Negating the salt iodization (USI) policy is not advisable, but it is also wrong to supplement iodine blindly.