酮基布洛芬是一有效的非甾体消炎药,常用于治疗各种急、慢性关节炎。与其它非甾体抗炎药一样,酮基布洛芬口服可产生一系列严重的副作用。据报道,近年来酮基布洛芬的局部应用已取得成功,由于药物直接作用于炎症部位,不仅起效迅速且局部浓度高。本文采用聚氧乙烯-聚氧丙烯嵌段的聚合物Poloxamer 407(普流罗尼F-127,简写为PF-127)作为凝胶形成剂制备酮基布洛芬凝胶,并考察其体外释药特性及影响因素。制备方法称取酮基布洛芬和PF-127 Ketoprofen is a potent non-steroidal anti-inflammatory drug commonly used in the treatment of various acute and chronic arthritis. Like other non-steroidal anti-inflammatory drugs, oral administration of ketoprofen can produce a series of serious side effects. It has been reported that, in recent years, the topical application of ketoprofen has been successful. As the drug acts directly on the site of inflammation, it not only has rapid onset and high local concentration. In this paper, polyoxyethylene-polyoxypropylene block polymer Poloxamer 407 (Pluronic F-127, abbreviated as PF-127) was used as gel forming agent to prepare ketoprofen gel, and its in vitro release was investigated Drug characteristics and influencing factors. Preparation Methods Weigh ketoprofen and PF-127