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目的分析合并恶性肿瘤的脑卒中患者的临床因素和D-二聚体水平。方法比较合脑卒中并恶性肿瘤患者28例(观察组)与无恶性肿瘤不明原因脑卒中患者58例(对照组A)以及有活动性肿瘤但无脑卒中组30例(对照组B),3组患者的临床因素、D-二聚体水平。结果观察组D-二聚体水平为3.08~25.67μg/ml,平均为10.67μg/ml;对照组A D-二聚体水平为0.29~1.01μg/ml,平均为0.45μg/ml;对照组B D-二聚体水平为0.40~1.35μg/ml,平均为0.67μg/ml。观察组血浆D-二聚体水平较对照组A和对照组B均明显升高,差异均有统计学意义(P<0.01)。结论脑卒中合并恶性肿瘤患者可能有独特的D-二聚体水平和病变模式,这些特征可以作为不明原因脑卒中患者发现隐匿恶性肿瘤的线索;合并恶性肿瘤的脑卒中患者预后差,早期发现并干预治疗,延长患者生存时间,提高生活质量。
Objective To analyze the clinical factors and D-dimer levels in stroke patients with malignant tumor. Methods A total of 28 patients with stroke and malignant tumor (observation group) and 58 patients with unexplained stroke without malignancy (control group A) and 30 patients with active tumor without stroke group (control group B) and 3 Group of patients with clinical factors, D-dimer levels. Results The level of D-dimer in the observation group was 3.08 ~ 25.67μg / ml with an average of 10.67μg / ml; the level of A-dimer in the control group was 0.29 ~ 1.01μg / ml with an average of 0.45μg / ml; B D-dimer levels ranged from 0.40 to 1.35 μg / ml with an average of 0.67 μg / ml. The level of D-dimer in observation group was significantly higher than that in control group A and control group B, with statistical significance (P <0.01). Conclusions Patients with stroke complicated with malignant tumors may have unique D-dimer levels and pathological patterns. These characteristics may serve as clues for concealing malignant tumors in stroke patients with unexplained causes. Stroke patients with malignant tumors have a poor prognosis and early detection Intervention treatment to extend the survival time of patients and improve the quality of life.