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目的：观察老年肝炎后肝硬化患者纤溶功能变化。方法：分别用发色底物法，酶联免疫吸附法测定４７例老年肝炎后肝硬化患者（ 老年组） ，３４ 例非老年肝炎后肝硬化患者（ 非老年组） 及２４ 例健康老年人（ 对照组） 外周血组织型纤溶酶原激活物活性（ｔ＿ｐ Ａ： Ａ） 及其抗原（ｔ＿ Ｐ Ａ： Ａｇ） 、纤溶酶原激活物抑制物活性（ Ｐ Ａ Ｉ： Ａ） 及 Ｄ－ 二聚体。结果：老年组与非老年组比较上述指标无显著性差异（ Ｐ＞ ０ ．０５） 。老年组ｔ＿ Ｐ Ａ： Ａ、ｔ－ ｐ Ａ： Ａｇ 及 Ｄ－ 二聚体显著高于肝功能代偿者（ Ｐ＜ ０ ．０１） ，而 Ｐ Ａ Ｉ： Ａ 显著低于对照组。老年组中肝功能失代偿者ｔ － Ｐ Ａ： Ａｇ 、ｔ－ Ｐ Ａ： Ａ 及 Ｄ－ 二聚体显著高于肝功能代偿者（ Ｐ＞ ０ ．０１） ， Ｐ Ａ Ｉ： Ａ 变化与之相反。结论：随着老年肝炎后肝硬化患者肝功能减退，其纤溶活性升高，纤溶功能状态与患者年龄无关。测定纤溶活化功能对预测其肝功能损害、出血、预后及指导治疗有重要意义。
Objective: To observe the changes of fibrinolytic function in elderly patients with liver cirrhosis. Methods: Seventy-seven patients with post-hepatitis cirrhosis (aged group), 34 non-elderly patients with cirrhosis (non-elderly group) and 24 healthy elderly (non-elderly) were measured by chromogenic substrate method and enzyme-linked immunosorbent assay (T_p A: A) and its antigen (t_ PA: Ag), plasminogen activator inhibitor activity (PAIA: A) and D- Dimer. Results: There was no significant difference between the elderly group and the non-elderly group (P> 0.05). The elderly group had significantly higher t P A: A, t-p A: Ag and D-dimer than those with compensated liver function (P <0.01), while P A I: A was significantly lower than the control group. In the elderly group, t - PA: Ag, t - P A: A and D - dimers in patients with decompensated liver function were significantly higher than those in compensated patients with hepatic decompensation (P> 0. 01) to the opposite. CONCLUSIONS: With the decline of liver function in elderly patients with posthepatitic cirrhosis, the fibrinolytic activity is increased, and the fibrinolytic function has nothing to do with the patient’s age. Determination of fibrinolytic activation of the prognosis of liver damage, bleeding, prognosis and guiding treatment is of great significance.