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最近发表的一些实验研究,着重观察了肝硬化对伴有铁贮存不正常患者的预后的重要性以及铁在肝硬化发病中的作用。在色素性肝硬化中,肝内铁的累积量是随年龄的增长而增长的,而且还观察到肝铁浓度超过其耐受阈值时,便能引起肝纤维化和肝硬化。在无酒精损害时,只有当肝铁浓度超过大约400微摩尔/每克千重(22.3mg/g) (大约相当于4.5毫克/每克湿组织重,或近似于正常值上限的10倍)才会引起肝纤维化或肝硬化。
Recently published experimental studies focused on the importance of cirrhosis in the prognosis of patients with abnormal iron stores and the role of iron in the pathogenesis of cirrhosis. In pigmented cirrhosis, the accumulation of iron in the liver increases with age, and it is also observed that hepatic fibrosis and cirrhosis can be caused when the concentration of hepatic iron exceeds its tolerance threshold. In the absence of alcoholic impaired hepatic iron concentrations were observed only when the heparin concentration exceeded about 400 micromoles / gram (22.3 mg / g) (equivalent to about 4.5 mg / gram of wet tissue weight, or approximately 10 times the upper limit of normal) Will cause liver fibrosis or cirrhosis.