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1,6-二磷酸果糖(fructose-l, 6-diphosphate, FDP)是存在于一切活细胞内糖代谢的中间产物。动物实验证明,外源性FDP可明显增加缺血心肌或正常灌注心肌中的三磷腺苷(ATP)含量。有人给麻醉狗的窦房结和房室结动脉内注入含腺苷酸的溶液,可使窦房结冲动发放减慢及房室结传导时间延长,临床上据此机制使用FDP治疗室上性心动过速取得一定疗效;我院用FDP治疗P-R间期延长则与治疗室上性心动过速所根据的原理截然相反,但临床治疗1例获显效,特报告如下。
Fructose-1 (6-diphosphate, FDP) is an intermediate product of glucose metabolism in all living cells. Animal experiments show that exogenous FDP can significantly increase myocardial ischemia or normal perfusion of myocardial adenosine triphosphate (ATP) content. Some anesthesia dogs to the sinus node and atrioventricular nodal injection of adenosine-containing solution can make sinus node impulse delivery slowed down and atrioventricular node conduction time, according to the clinical use of this mechanism FDP treatment of supraventricular Tachycardia achieved some effect; our hospital with FDP PR interval prolongation and treatment of supraventricular tachycardia based on the principle of the opposite, but the clinical treatment of 1 case was markedly effective, the special report is as follows.