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目的探讨支气管肺泡灌洗(BAL)并局部注入敏感抗生素治疗支气管扩张合并感染的临床疗效。方法 62例支气管扩张合并感染患者随机分为治疗组和对照组,对照组给予常规治疗,治疗组在常规治疗的基础上给予BAL并局部注入敏感抗生素治疗。治疗前后测定动脉血氧分压(PaO2)、二氧化碳分压(PaCO2)、血氧饱和度(SaO2)血气分析指标;疗程结束后评价临床疗效;痊愈出院时计算住院时间和住院费用。结果治疗组临床疗效总有效率为96.9%,显著高于对照组76.7%(P<0.05);两组患者血气分析指标显著上升,与治疗前比较均有显著性差异(P<0.05),且治疗组与对照组比较血气指标上升更显著(P<0.05);治疗组住院时间和总住院费用显著低于对照组(P<0.05)。结论 BAL并局部注入敏感抗生素治疗支气管扩张合并感染临床效果明显,值得临床上推广应用。
Objective To investigate the clinical efficacy of bronchoalveolar lavage (BAL) and local injection of sensitive antibiotics in the treatment of bronchiectasis complicated with infection. Methods Sixty-two patients with bronchiectasis and infection were randomly divided into treatment group and control group. The control group was given routine treatment. The treatment group was given BAL and the local injection of sensitive antibiotics was given on the basis of routine treatment. PaO2, PaCO 2 and SaO 2 were measured before and after treatment. The curative effect was evaluated after the course of treatment was completed. The hospitalization and hospitalization expenses were calculated when discharged. Results The total effective rate of the treatment group was 96.9%, significantly higher than that of the control group (76.7%, P <0.05). The indexes of blood gas analysis increased significantly in both groups, which were significantly different from those before treatment (P <0.05) Compared with the control group, the blood gas index increased more significantly in the treatment group and the control group (P <0.05). The hospitalization time and total hospitalization cost in the treatment group were significantly lower than those in the control group (P <0.05). Conclusion BAL and local injection of sensitive antibiotics in the treatment of bronchiectasis with clinical significant effect, it is worth promoting the clinical application.