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抗菌增效剂甲氧苄氨嘧啶(简称TMP)是一新型的抗菌药物,国外1968年用于临床,国产品1972年正式投产并用于临床。其抗菌谱与磺胺药相似而抗菌作用较强,国外报导0.1～10微克/ml几乎可抑制所有致病菌,对大多数致病菌最低抑菌浓度低于2微克/ml;我们对1455株细菌作抑菌实验,总抑菌率为72.2％,其中对痢疾、大肠和伤寒杆菌、金葡菌和乙型链球菌的作用尤强,抑菌率均在80％以上,对产气、副大肠和变形杆菌、白葡菌的抑菌率为51.7％～70.8％,对绿脓、产硷杆菌和脑膜炎球菌的作用很差,抑菌率仅为0～7.4％。由于与磺胺药和抗生素合用有增效作用,故有抗菌增效剂之称。TMP与多种磺胺药联合增效倍数敏感菌可达32～64倍,对耐药菌株也可达4～32倍,
Antibacterial synergist Trimethoprim (referred to as TMP) is a new type of antimicrobial drugs, used abroad in 1968 for clinical, domestic products formally put into operation in 1972 and used in clinical. Its antimicrobial spectrum and sulfa drugs similar to the strong antibacterial effect of foreign reports of 0.1 to 10 micrograms / ml can inhibit almost all pathogens, the minimum inhibitory concentration of most of the pathogenic bacteria less than 2 micrograms / ml; our 1455 strains Bacteria for antibacterial experiments, the total inhibitory rate of 72.2%, of which dysentery, large intestine and Salmonella typhi, Staphylococcus aureus and Streptococcus bite particularly strong role, the antibacterial rate were more than 80% of the gas, vice Staphylococcus aureus, Staphylococcus aureus and Staphylococcus aureus were 51.7% ~ 70.8%. The effects on P. aeruginosa, C. alkalis and meningococcus were very poor with the inhibition rates of 0 ~ 7.4%. As with sulfa drugs and antibiotics synergistic effect, it is said antibacterial synergist. TMP with a variety of sulfa drugs synergistic multiples of sensitive up to 32 to 64 times, up to 4 to 32 times the resistant strains,