Objective:Natural products of plant origin are potential source of novel antimicrobial and antioxidative agents.Thottea siliquosa(Lam.)Ding Hou.(T.siliquosa).A medicinal herb used by local tribals for treating various ailments.The present study aims at the phytochemical screening,GC-MS analysis,in vitro antibacterial activity and antioxidant potentiality of root and leaf extracts of T.siliquosa.Methods:Hot continuous Soxhlct extraction,GC-MS analysis,antibacterial analysis by disc diffusion,microdilution assay and antioxidant potentialities by hydroxyl radical and nitric oxide radical scavenging.The data was statistically analyzed.Results:Phytochemical screening of the ethyl acetate and methanolic extract of leaf and root revealed the presence of phenols,alkaloids,tannins and saponin.The extract revealed a pool of phytochemicals by comparison with authentic standards from spectral library.Both the extracts has shown their broad spectrum of inhibition against the selected bacteria Staphylococcus aureus,Escherichia coli,Pseudomonas aeruginosa and Klebsiella pneumonia compared with standard antibiotic drug streptomycin.The extracts showed antioxidant activity by scavenging of free radicals such as hydroxyl and nitric oxide.The IC_(50)values of the ethyl acetate extracts leaf and root and standard in this assay were I67.5±0.67,99.4±1.2,192±2.5μg/mL respectively.Similarly those methanolic extracts of leaf and root were 269.5±0.89 and 289.1±2.66μg/mL respectively.Similarly,ethyl acetate and methanolic extracts also caused a moderate dose-dependent inhibition of nitric oxide with an IC_(50)range 65.5±1.55 to 148±3.09μg/mL.The inhibitory activities were found to be dose dependent.Conclusion:The present study provides evidence that ethyl acetate and methanol extract of leaf and root of T.siliquosa are potential source of natural antioxidants and bactericidal nature.It is essential that research should continue to isolate and purify the bio active components of this natural plant and use in drug discovery and development. Objective: Natural products of plant origin are potential source of novel antimicrobial and antioxidative agents. Thottea siliquosa (Lam.) Ding Hou. (T.siliquosa). A medicinal herb used by local tribals for treating various ailments. The present study aims at the phytochemical screening, GC-MS analysis, in vitro antibacterial activity and antioxidant potentiality of root and leaf extracts of T. siliquosa. Methods: Hot continuous Soxhlct extraction, GC-MS analysis, antibacterial analysis by disc diffusion, microdilution assay and antioxidant potentialities by hydroxyl radical and nitric oxide radical scavenging. the data was exactly analyzed. Results: Phytochemical screening of the ethyl acetate and methanolic extract of leaf and root revealed the presence of phenols, alkaloids, tannins and saponin. extract revealed a pool of phytochemicals by comparison with authentic standards from spectral library.Both the extracts has shown their broad spectrum of inhibition against the selected bacteria Staph ylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumonia compared with standard antibiotic drug streptomycin. The extracts showed antioxidant activity by scavenging of free radicals such as hydroxyl and nitric oxide. The IC 50 values ​​of the ethyl acetate extracts leaf and root and standard in this assay were I67.5 ± 0.67, 99.4 ± 1.2, 192 ± 2.5 μg / mL respectively. Similarity to those methanolic extracts of leaf and root were 269.5 ± 0.89 and 289.1 ± 2.66 μg / mL respectively.Similarly, ethyl acetate and methanolic Also caused a moderate dose-dependent inhibition of nitric oxide with an IC 50 range of 65.5 ± 1.55 to 148 ± 3.09 μg / mL. The inhibitory activities were found to be dose dependent. Confluence: The present study provides evidence that ethyl acetate and methanol extract of leaf and root of T.siliquosa are potential source of natural antioxidants and bactericidal nature. It is essential that research should continue to isolate and purify the bio active components of this natural plant and use in drug discovery and development.