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他克莫司(FK506)是一种强效免疫抑制剂,主要应用于预防和治疗器官移植后的排异反应。为了解血中红细胞压积(Hct)、血红蛋白浓度(Hb)、白蛋白(Alb)、胆固醇(ch)、甘油三酯(Tc)对FK506相对清除率的影响,本文对19例肾移植术后因肝肾功能损害转换为他克莫司的患着进行了相关性分析,以期为临床合理使用他克莫司提供参考。
Tacrolimus (FK506) is a potent immunosuppressive agent that is mainly used to prevent and treat rejection after organ transplantation. In order to understand the effects of hematocrit (Hct), hemoglobin (Hb), albumin (Alb), cholesterol (Ch) and triglyceride (Tc) on the relative clearance of FK506, Correlation analysis was made about the conversion of liver and kidney dysfunction to tacrolimus in order to provide a reference for clinical use of tacrolimus.