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Objective To evaluate the effects and mechanisms of glucose-insulin-potassium (GIK) on post-procedural myocardial injury (PMI) after percutaneous coronary intervention (PCI).Methods A total of 200 non-diabetic patients with documented coronary heart disease (CHD) were divided into the Group GIK and Group G,with 100 patients in each group.Patients in Group G were given intravenous infusion of glucose solution 2 hours before PCI.As compared,patients in Group GIK were given GIK.Results Both post-procedural creatine phosphokinase isoenzyme MB (CK-MB;62.1 ± 47.8 vs.48.8 ± 52.6 U/L,P =0.007) and cTnI (0.68 ± 0.83 vs.0.19 ± 0.24 ng/mL,P ＜ 0.001) in Group GIK were significantly higher than those in Group G.In Group G,9.0％ and 4.0％ of patients had post-procedural increases in CK-MB 1-3 times and ＞ 3 times,which were significantly lower than those in Group GIK (14.0％ and 7.0％,respectively;all P values ＜ 0.01);13.0％ and 7.0％ of patients had post-procedural increases in cTnI 1-3 times and ＞ 3 times,which were also significantly lower than those in Group GIK (21.0％ and 13.0％,respectively;all P ＜ 0.001).Pre-procedural (10.2 ± 4.5 vs.5.1 ± 6.3,P ＜ 0.001) and post-procedural rapid blood glucose (RBG) levels (8.9 ± 3.9 vs.5.3 ± 5.6,P ＜ 0.001) in Group G were higher than those in Group GIK.In adjusted logistic models,usage of GIK (compared with glucose solution) remained significantly and independently associated with higher risk of post-procedural increases in both CK-MB and cTnI levels ＞ 3 times.Furthermore,pre-procedural RBG levels ＜ 5.0mmol/L were significantly associated with higher risk of post-procedural increases in both CK-MB and cTnI levels.Conclusions In non-diabetic patients with CHD,the administration of GIK may increase the risk of PMI due to hypoglycemia induced by GIK.