论文部分内容阅读
目的分析肝细胞生长因子受体(C-met)、结肠癌转移相关基因1(MACC1)蛋白在食管癌组织中的表达及临床意义。方法选取2013年3月至2015年4月武汉市东湖医院胸外科手术切除后经病理学检查证实为食管癌的癌组织69例及食管癌癌旁组织30例,采取免疫组化染色检测其中的MACC1和C-met蛋白表达水平,并分析其表达水平与患者的临床病理特征的关系。结果食管癌组织中的MACC1、C-met蛋白阳性表达率分别为84.06%、75.36%,显著高于癌旁组织的30.00%、23.33%,差异均有统计学意义(P<0.05)。食管癌组织中的MACC1、C-met蛋白阳性表达与食管癌的分化程度、TNM分期、发生淋巴结转移具有显著的相关性(P<0.05)。结论MACC1、C-met蛋白在食管癌组织中表达上调,并且与食管癌的发生、发展具有一定的关系。
Objective To analyze the expression and clinical significance of hepatocellular growth factor receptor (C-met) and colon cancer metastasis-associated gene 1 (MACC1) protein in esophageal cancer. Methods From March 2013 to April 2015, 69 cases of esophageal cancer tissues and 30 cases of esophageal cancer adjacent tissues confirmed by pathology after resection of the thoracic surgery in Donghu Hospital of Wuhan City were selected for immunohistochemical staining MACC1 and C-met protein expression levels, and analyze the relationship between the expression level and the clinicopathological features of patients. Results The positive rates of MACC1 and C-met protein in esophageal cancer tissues were 84.06% and 75.36%, respectively, which were significantly higher than those in paracancerous tissues (30.00% and 23.33%, P <0.05). The positive expression of MACC1 and C-met protein in esophageal cancer tissues was significantly correlated with the differentiation of esophageal cancer, TNM stage and lymph node metastasis (P <0.05). Conclusions The expressions of MACC1 and C-met proteins are up-regulated in esophageal cancer tissues and have a certain relationship with the occurrence and development of esophageal cancer.