Objective:To assess the possible benefit of food supplementation with the nutriceuticalImprove? for the treatment of the infertile couple.Methods:The treatment of diseases causing male or female infertility should be completed by the prescription of a judiciously formulated composite nutriceutical(Improve?NutriphytInc,Oostkamp,Belgium) which counteracts the pathogenic mechanisms involved in sperm and oocyte dysfunction, enhances cellular energy production, corrects oxidation-induced damage to the cell membrane and toDNA, and repairs mitochondrial insufficiency.The efficiency of this nutraceutical was tested in controlled trials and in assisted reproduction, including1888 infertile couples.Results:Complementary food supplementation with the nutriceuticalImprove? plus linseed oil improved the quantity and functional quality of spermatozoa, significantly increasing their fertilizing potential.This supplement with added fish oil enhanced female fertility with higher probablity of natural conception and ongoing pregnancy using techniques of assisted reproduction.Conclusions:Complementary food supplementation with the nutriceuticalImprove? has significant beneficial effects for the treatment of the infertile couple and reduces the cost per delivery.