Perioperative changes in lower gut microbiocenosis in patients with colon and rectum cancer

来源 :新疆医科大学学报 | 被引量 : 0次 | 上传用户:vay_b
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This clinical study was designed to determinate the value of colon microbiota microflora in colorectal cancer patients.We investigate pre-and post-operation stool samples in patients with different tumor localizations,trying to correlate those to postoperative complications.Our findings shows that if opportunistic pathogenic microflora levels are elevated before operations,it can lead to further microbiota disbalance in postoperative period,especially in cases of antibacterial prophylaxis or treatment.Further,this changes increase a chance of receiving some complications after surgery.So,we suggest an analysis of stool microbiota in patients with colorectal cancer to be performed prior and after the operation.Furthermore,aperioperative decontamination therapy should be performed in cases of pathogenic microflora levels elevation.Still,monitoring aperioperative microbiota changes is not a routine in most recommendations and we assume that including this relatively unencumbered patient testing in preoperative survey will help to reduce a number of postoperative complications. This clinical study was designed to determinate the value of colon microbiota microflora in colorectal cancer patients. We investigate pre-and post-operation stool samples in patients with different tumor localizations, trying to correlate those to postoperative complications. Our findings shows that if opportunistic pathogenic microflora levels are elevated before operations, it can lead to further microbiota disbalance in postoperative period, especially in cases of antibacterial prophylaxis or treatment. Further, this changes increase a chance of receiving some complications after surgery. So, we suggest an analysis of stool microbiota in patients with colorectal cancer to be performed prior and after the operation. Focus of, aperioperative decontamination therapy should be performed in cases of pathogenic microflora levels elevation. titill, monitoring aperioperative microbiota changes is not a routine in most recommendations and we assume that the including the unencumbered patient t esting in preoperative survey will help to reduce a number of postoperative complications.
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