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氨茶碱是1970年汇集的存在生物有效性差异的药物品种。1973年英国药学会提出需要进行生物利用度测定的40种药品,其中亦包括氨茶碱。1977年报道了不同药厂生产的氨茶碱片体外溶出速度有差异。然而,对长效氨茶碱片的生物利用度研究尚未见报道。我们对二家不同厂的氨茶碱片其体外释放度和体内生物利用度进行研究。现将结果简介如下:
Aminophylline is a medicinal product that has been pooled in 1970 for differences in bioavailability. In 1973 the British Pharmaceutical Association proposed the need for bioavailability determination of 40 kinds of drugs, including aminophylline. In 1977 reported that different pharmaceutical manufacturers aminophylline tablets in vitro dissolution rate differences. However, the bioavailability of long-acting aminophylline tablets has not been reported. We studied the in vitro release and in vivo bioavailability of aminophylline tablets from two different factories. Now the results are as follows: