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目的:探讨宫颈鳞状上皮内瘤变(CIN)治疗后影响高危型人乳头瘤病毒(HR-HPV)清清除的相关因素。方法:对2008年10月至2009年12月在新疆自治区人民医院经阴道镜下活检诊断为CIN并采用第二代杂交捕获技术(HC2)检测HR-HPV阳性的90例患者进行宫颈锥切术,术后6月采用HC2技术行宫颈HR-HPV检测,对CIN治疗后影响HR-HPV清除的相关因素进行回顾性分析。结果:CIN治疗后切缘阳性组与切缘阴性组,治疗前高危型HPV病毒载量≥500RLU/PC组与<500RLU/PC组术后HR-HPV持续阳性率有差异。结论:切缘阳性及术前HR-HPV病毒载量≥500RLU/PC者宫颈锥切术后HR-HPV难以消除,应严密随访。
Objective: To investigate the related factors affecting the clearance of high-risk human papillomavirus (HR-HPV) after cervical squamous intraepithelial neoplasia (CIN) treatment. Methods: From October 2008 to December 2009, 90 cases of HR-HPV positive were diagnosed as CIN by colposcopic biopsy in People’s Hospital of Xinjiang Uygur Autonomous Region and HR2 HPV test by second-generation hybridization capture technique (HC2) , HC2 technique was used to detect cervical HR-HPV in June after operation, and the related factors affecting HR-HPV clearance after CIN treatment were analyzed retrospectively. Results: The positive rate of HR-HPV in the patients with positive margins and negative margins after CIN treatment were higher than those before the treatment. The pre-treatment high-risk HPV viral load≥500 RLU / PC group and <500 RLU / PC group were different. Conclusion: HR-HPV after positive conization and preoperative HR-HPV viral load≥500 RLU / PC can not be eliminated after cervical conization, and should be closely followed up.