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目的 评价神经节苷脂 (GM1 )治疗急性脑出血的效果。方法 急性脑出血患者 86例 ,随机分为两组。治疗组 40例 ,给予 GM1 40～ 6 0 m g加入生理盐水 2 5 0 ml内静滴 ,连续 15天 ;对照组 46例 ,给予胞二磷胆碱治疗。于治疗前、治疗终、2个月后对两组病人进行神经功能缺损程度及日常生活活动量评分 ,并进行比较。结果 GM1 治疗组与对照组相比治疗终、治疗 2个月后神经功能缺损程度评分、日常生活活动量评分均有极显著的差异 (均 P<0 .0 1)。结论 GM1 治疗有明显的神经保护作用 ,能促进神经功能的早期恢复 ,降低致残率。
Objective To evaluate the effect of ganglioside (GM1) in the treatment of acute cerebral hemorrhage. Methods Acute cerebral hemorrhage in 86 patients were randomly divided into two groups. The treatment group, 40 cases, given GM1 40 ~ 60 m g added intravenous infusion of 250 ml normal saline for 15 days; control group of 46 patients were given citicoline treatment. Before treatment, after treatment, two groups of patients after 2 months of neurological deficits and daily living activity score, and compared. Results Compared with the control group, the GM1 treatment group had a significant difference in the scores of neurological deficit scores and activities of daily living after 2 months of treatment (all P <0.01). Conclusion GM1 has obvious neuroprotective effect, which can promote the early recovery of neurological function and reduce the morbidity.