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目的：研究高能聚焦超声（ＨＩＦＵ）辐射治疗对小鼠皮下移植肿瘤的可行性。方法：采用已建立的小鼠皮下可移植性膀胱肿瘤模型，用国内研制的ＨＩＦＵ仪对皮下荷瘤鼠进行了实验研究。实验分为：治疗组小鼠４５只，采用超声强度７００Ｗ／ｃｍ２的ＨＩＦＵ对小鼠皮下移植瘤进行辐照治疗；对照组小鼠４５只，不采用任何处理。观察治疗后荷瘤鼠生存时间，生长曲线，以及治疗后靶组织的光镜、电镜下改变。结果：平均生存时间：治疗组３７．２０±８．２２天，对照组１４．０７±２．４６天（Ｐ＜０．０１）。ＨＩＦＵ治疗后肿瘤组织呈灰白色，治疗区皮肤无灼伤，治疗后３ｈ，靶区瘤细胞肿胀，并可见点状坏死，１周时出现了边界清楚的凝固性坏死区。结论：ＨＩＦＵ可以明显抑制移植性膀胱肿瘤
Objective: To study the feasibility of high-energy focused ultrasound (HIFU) radiation treatment on mice subcutaneously transplanted tumors. Methods: The mouse model of subcutaneously transplanted bladder tumor was established and the subcutaneous tumor-bearing mice were studied by HIFU instrument developed in China. The experiment was divided into: The treatment group of 45 mice, the use of ultrasound intensity 700W / cm2 of HIFU subcutaneous transplanted tumor in mice irradiated; control group of 45 mice, without any treatment. After treatment, the survival time and growth curve of tumor-bearing mice were observed, and the light and electron microscopic changes of target tissues were observed. Results: The mean survival time was 37.20 ± 8.22 days in the treatment group and 14.07 ± 2.46 days in the control group (P <0.01). After HIFU treatment, the tumor tissue was gray and the skin of the treatment area was absent. After 3 hours of treatment, the tumor cells in the target area were swollen and spotted necrosis was seen. At 1 week, a clear coagulation necrosis area appeared. Conclusion: HIFU can significantly inhibit the transplanted bladder tumor