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目的探讨EphB6蛋白在结直肠癌中的表达及其临床意义。方法采用免疫组织化学染色检测82例结直肠癌组织与癌旁组织中EphB6蛋白的表达,并比较两者表达的差异;分析EphB6蛋白与结直肠癌临床病理特征的关系;分析有随访资料的49例患者EphB6蛋白表达与预后的关系。结果与癌旁组织相比,结直肠癌组织EphB6蛋白表达下调40例(48.8%),表达上调14例(17.1%),无变化28例(37.1%)。结直肠癌组织EphB6蛋白表达下调者多为中晚期(P=0.015)或淋巴结转移者(P=0.048),但与肿瘤分化无明显相关。结直肠癌组织EphB6蛋白表达下调组和无变化组的中位生存时间分别为34个月和33个月,上调组的生存时间较长(中位生存时间为未达到),3组差异接近有统计学意义(P=0.052)。结论EphB6基因在结直肠癌的发展过程中可能有一定抑制肿瘤转移及发展的作用,该蛋白有可能成为结直肠癌预后的新指标。
Objective To investigate the expression of EphB6 protein in colorectal cancer and its clinical significance. Methods Immunohistochemical staining was used to detect the expression of EphB6 protein in 82 cases of colorectal cancer tissue and its adjacent tissues. The differences of the expression of EphB6 protein and the clinicopathological characteristics of colorectal cancer were analyzed. The follow-up data of 49 Relationship Between EphB6 Protein Expression and Prognosis in Patients. Results The expression of EphB6 protein in colorectal cancer tissues was down-regulated by 40.8% (48.8%), and 14 cases (17.1%) were up-regulated with no change in 28 cases (37.1%). The expression of EphB6 protein in colorectal cancer was mostly decreased in the advanced stage (P = 0.015) or lymph node metastasis (P = 0.048), but not significantly correlated with tumor differentiation. The median survival time of EphB6 protein expression in colorectal cancer tissues was 34 months and 33 months, respectively, and the survival time of the up-regulated group was longer (median survival time was not reached). The differences between the three groups were close Statistical significance (P = 0.052). Conclusion EphB6 may play a role in tumor metastasis and development in the development of colorectal cancer. The protein may be a new prognostic indicator of colorectal cancer.