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肝炎协同抗原(Au)已在若干胶原性疾病中发现。我们对50例风湿热病人及25名对照组健康儿童(年龄5～15岁)的血清标本作了Au检查,使用方法是琼脂凝胶免疫扩散及微量补体结合试验。这些病人过去无输血史、感染及肝炎史、肝功能检查(包括SGPT)均正常,但血沉降率和抗链球菌滴度全部均升高。1例Au阳性病人肝活体组织检查在光学显微镜下所见正常。我们将风湿热病人分为两组:甲组,40例风湿热病人伴有活动性心脏病;乙组,10例风湿热病人伴有关节炎,但无心脏病。甲组中有13例(32.5％)发现Au阳性,而乙组仅有1例,对照组有2例(8％)发现Au。
Hepatitis Synergistic Antigen (Au) has been found in several collagen diseases. We examined 50 serum samples of rheumatic fever and 25 healthy children (aged 5-15 years) from control group using agar gel immunodiffusion and micro-complement fixation test. In the past, these patients had no history of blood transfusion, history of infection and hepatitis, and liver function tests (including SGPT) were normal, but all had elevated blood sedimentation rates and anti-streptococcal titers. One case of Au positive patients with liver biopsy under normal light microscope. We divided the patients with rheumatic fever into two groups: Group A, 40 patients with rheumatic fever accompanied by active heart disease; Group B, 10 patients with rheumatic fever accompanied by arthritis, but no heart disease. In group A, 13 (32.5%) were found to be Au positive, while only 1 in group B and 2 (8%) in control group.