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为了动态观察西地那非治疗中风大鼠的长期反应,Li L等人进行了一项研究,研究者将雄性Wistar大鼠中风造模后,分为西地那非组(n=11)或生理盐水组(n=10),中风后24h内给予单次剂量10mg/kg每日皮下注射共6d。衡量所有动物在中风后第1天、第2天及6周内每周的磁共振图象和功能表现。所有动物在中风6周后处死,使用血管内皮屏障抗原免疫学检查,来进行脑血管的形态学和量化分析。虚拟数据图象(MAP-ISODATA)根据T(1),T(2)和T(1sat)图像计算获得。虚拟数据图象能特异性获得缺血损伤程度。基于
In order to dynamically observe the long-term response of sildenafil to the treatment of stroke in rats, Li L et al. Conducted a study in which male Wistar rats were divided into sildenafil (n = 11) or Saline group (n = 10), given a single dose of 10mg / kg subcutaneously daily for 6 days after 24h of stroke. All animals were screened weekly for magnetic resonance imaging and functional performance on days 1, 2 and 6 after stroke. All animals were sacrificed 6 weeks after the stroke and immunological tests using vascular endothelial barrier antigen were performed for morphological and quantitative analysis of cerebrovascular. The virtual data image (MAP-ISODATA) is calculated from T (1), T (2) and T (1sat) images. Virtual data images can specifically obtain the degree of ischemic injury. based on