论文部分内容阅读
目的观察血压正常高值(PH)及合并空腹血糖受损(IFG)患者血清肿瘤坏死因子α(TNF-α)及肝细胞生长因子(HGF)的变化,探讨TNF-α及HGF在PH发生发展中的作用及意义。方法根据2005年中国高血压防治指南,入选200例健康体检者分为PH组(n=140)和正常血压组(NT,n=60),均未服降压药。依据空腹血糖水平分成3组:NT+低空腹血糖(LFG,空腹血糖<5.6mmol/L)组(n=60);PH+LFG(<5.6mmol/L)组(n=70);PH+HFG(高空腹血糖,空腹血糖5.6～6.9mmol/L)组(n=70)。用酶联免疫吸附试验(ELISA)分别检测血清TNF-α及HGF水平。结果 PH+LFG组TNF-α、HGF明显高于NT+LFG组[TNF-α:PH+LFG组(70.99±7.00)比NT+LFG组(59.76±8.16)ng/L;HGF:PH+LFG组(487.74±46.11)比NT+LFG组(435.17±58.01)ng/L,均P<0.01]。PH+HFG组TNF-α、HGF明显高于PH+LFG组[TNF-α:PH+HFG组(76.27±6.80)比PH+LFG组(70.99±7.00)ng/L,P<0.01;HGF:PH+HFG组(504.59±54.49)比PH+LFG组(487.74±46.11)ng/L,P<0.05]。Pearson相关分析示TNF-α与HGF呈正相关。多因素回归分析显示HGF与收缩压、空腹血糖呈正相关。结论 PH患者血清TNF-α、HGF较正常血压者明显升高,合并IFG时TNF-α、HGF进一步升高,提示PH阶段可能已存在炎症性内皮细胞损伤与修复,当合并IFG时,炎症性内皮细胞损伤和修复更明显。
Objective To investigate the changes of serum tumor necrosis factor-α (TNF-α) and hepatocyte growth factor (HGF) in patients with normal high blood pressure (PH) and impaired fasting glucose (IFG) In the role and significance. Methods According to the guideline of prevention and treatment of hypertension in China in 2005, 200 healthy subjects were divided into PH group (n = 140) and normotensive group (NT, n = 60) without any antihypertensive drugs. According to the fasting blood glucose level, the patients were divided into three groups: NT + low fasting blood glucose (LFG, fasting blood glucose <5.6mmol / L) group (n = 60); PH + LFG (High fasting blood glucose, fasting glucose 5.6 ~ 6.9mmol / L) group (n = 70). Serum levels of TNF-α and HGF were detected by enzyme linked immunosorbent assay (ELISA). Results The levels of TNF-α and HGF in PH + LFG group were significantly higher than those in NT + LFG group [(70.99 ± 7.00) vs that in NT + LFG group (59.76 ± 8.16) ng / L; Group (487.74 ± 46.11) than NT + LFG group (435.17 ± 58.01) ng / L, both P <0.01]. The levels of TNF-α and HGF in PH + HFG group were significantly higher than those in PH + LFG group [(76.27 ± 6.80) vs 70.99 ± 7.00 ng / L (P <0.01) PH + HFG group (504.59 ± 54.49) than PH + LFG group (487.74 ± 46.11) ng / L, P <0.05]. Pearson correlation analysis showed a positive correlation between TNF-α and HGF. Multivariate regression analysis showed that HGF was positively correlated with systolic blood pressure and fasting blood glucose. Conclusion The levels of serum TNF-α and HGF in patients with PH are significantly higher than those in patients with normal blood pressure. The levels of TNF-α and HGF in patients with PHG are further increased, suggesting that inflammatory cell injury and repair may exist in PH stage. When IFG is combined with inflammatory cytokines Endothelial cell damage and repair more obvious.