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随着近年来迅速崛起的心、脑血管介入治疗学和外周放射介入治疗以及多种医学影像学检查技术的发展;含碘对比剂即对比剂的大量应用临床。由此引起的急性肾损伤已成为不可忽视的临床问题。据统计[1],对比剂是造成住院病人急性肾损伤的主要原因之一,在院内获得性急性肾损伤中位列第三。为此,了解对比剂的肾毒性机制从而预防对比剂肾病的发生具有重大意义。本文就近年来对比剂肾病的定义和诊断标准、危险因素、发病机制及预防等方面的研究进展综述如下。
With the rapid rise of the recent years, cardiovascular interventional therapy and peripheral radiological interventional therapy and a variety of medical imaging technology development; iodine contrast agent that is a large number of clinical application of contrast agent. The resulting acute kidney injury has become a clinical issue that can not be ignored. According to statistics [1], contrast agents is one of the main causes of acute kidney injury in hospitalized patients, and ranks third in hospital acquired acute renal injury. To this end, understanding the nephrotoxicity mechanism of contrast agents and thus preventing the occurrence of contrast agent nephropathy is of great significance. In this paper, the definition and diagnostic criteria of contrast agent nephropathy in recent years, risk factors, pathogenesis and prevention of research progress are summarized below.