论文部分内容阅读
[目的]观察替加氟对中晚期食管癌放疗增敏效果及不良反应。[方法]将96例初治中晚期食管癌患者随机分成观察组与对照组,每组48例,均采用直线加速器6MV-X线进行外照射放疗,总剂量60~66Gy/6~7周,2Gy/次,5次/周。观察组在放疗的同时口服替加氟,每次0.1~0.2g,3次/d,至放疗结束。比较2组近期疗效及不良反应的差异。[结果]观察组近期有效率为83.33%,对照组为60.42%,2组比较差异有统计学意义(P<0.05);观察组不良反应较对照组稍明显,但2组比较差异无统计学意义(P>0.05)。[结论]替加氟能增加食管癌放疗的放射敏感性,提高食管癌的近期有效率;不良反应无明显增加。
[Objective] To observe the effect and adverse reactions of tegafur on radiosensitivity of advanced esophageal cancer. [Methods] 96 patients with newly diagnosed advanced esophageal cancer were randomly divided into observation group and control group, 48 cases in each group. External beam radiotherapy was performed with 6MV-X linear accelerator, the total dose was 60-66 Gy / 6-7 weeks, 2Gy / time, 5 times / week. Observation group in the radiotherapy at the same time oral tegafur, each 0.1 ~ 0.2g, 3 times / d, to the end of radiotherapy. Compare the short-term efficacy and adverse reactions in the two groups. [Results] The effective rate of the observation group was 83.33%, while that of the control group was 60.42%. The difference between the two groups was statistically significant (P <0.05). The adverse reactions of the observation group were slightly more obvious than those of the control group, but there was no statistical difference between the two groups Significance (P> 0.05). [Conclusion] Tegafur can increase the radiosensitivity of esophageal cancer radiotherapy and improve the recent efficiency of esophageal cancer; no significant increase in adverse reactions.