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ａｐｏＡ－Ⅰ转基因和基因灭活小鼠的产生、ａｐｏＡ－Ⅰ体细胞基因转移以及给实验性动脉粥样硬化兔注射同种ａｐｏＡ－Ⅰ的研究，证明ａｐｏＡ－Ⅰ具有直接抗动脉粥样硬化作用及防治应用价值。ａｐｏＡ－Ⅰ分子结构及前β高密度脂蛋白（ｐｒｅ－βＨＤＬ）的研究进一步阐明了ａｐｏＡ－Ⅰ在胆固醇逆转运及抗动脉粥样硬化中的作用机理。
apoA-I transgenic and gene-inactivated mice, gene transfer of apoA-I somatic cells, and injection of the same apoA-I to experimental atherosclerotic rabbits demonstrated that apoA-I has a direct anti-atherogenic effect And prevention and treatment of application value. Studies on the molecular structure of apoA-Ⅰ and pre-β-HDL further elucidate the mechanism of action of apoA-Ⅰ on cholesterol reverse transport and anti-atherosclerosis.