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目的:观察二甲双胍联合达因-35治疗多囊卵巢综合征(PCOS)的疗效。方法:PCOS患者104例,随机分为治疗组56例,口服达因-35联合二甲双胍治疗;对照组48例,口服二甲双胍治疗;2组在用药3个月后停药,均用来曲唑+人绒毛促性腺激素促排卵治疗,观察比较2组患者促卵泡激素(FSH)、血清睾酮(T)、促黄体激素(LH)、空腹胰岛素(FINS)、空腹血糖(FPG)水平、排卵率和妊娠率。结果:治疗组治疗后LH、T及FPG水平均好于对照组(P<0.01),2组间FSH和FINS、黄素化未破裂卵泡综合征、排卵率、妊娠率差异均无统计学意义(P>0.05)。结论:达因-35二甲双胍联合能有效改善PCOS患者激素分泌情况,但是对于排卵与妊娠情况无影响。
Objective: To observe the curative effect of metformin combined with dynan-35 on polycystic ovary syndrome (PCOS). Methods: One hundred and four patients with PCOS were randomly divided into treatment group (n = 56) and oral darin (n = 35) combined with metformin. The control group (n = 48) was treated with metformin orally. Human chorionic gonadotropin and ovulation induction therapy were observed. The levels of FSH, serum testosterone, LH, FINS, FPG and ovulation rate were compared between the two groups. Pregnancy rate. Results: The levels of LH, T and FPG in the treatment group were better than those in the control group (P <0.01). There was no significant difference in FSH, FINS, luteinized unruptured follicle syndrome, ovulation rate and pregnancy rate between the two groups (P > 0.05). Conclusion: Combination of darin and metformin can effectively improve hormone secretion in patients with PCOS, but has no effect on ovulation and pregnancy.