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目的探讨松果体内毛细血管和松果体细胞分泌颗粒的超微结构特征及其意义。方法采用常规生物电镜样品制备技术，对成年日本猴松果体进行了透射电镜观察。结果猴松果体血管及毛细血管只存在于被囊和小叶间隔的结缔组织内，松果体实质小叶内并无血管。毛细血管内皮为窗孔（５０ｎｍ）型，外有基膜与血管周围结缔组织分隔。松果体实质小叶主要由松果体细胞和少数胶质细胞组成。松果体细胞的突起终止于血管周隙内；分泌颗粒大量存在于松果体细胞突起的杵状终末或偶尔见于结缔组织间隙内；分泌颗粒为直径２００～５００ｎｍ的大型膜包密芯颗粒。结论这些超微结构特征提示：松果体细胞分泌颗粒的外排形式可能为整体释放而非胞吐分泌；分泌颗粒内的物质更象神经多肽而非生物源胺；松果体分泌物更易经组织信息通道释放入脑脊液而非透过毛细血管壁进入血液。
Objective To investigate the ultrastructural features of the secretory granules of capillaries and pineal gland cells in pineal gland and its significance. Methods Conventional bioelectron microscopy sample preparation techniques were used to observe the adult Japanese pineal tissues. Results The blood vessels and capillaries of the monkey pineal gland were only found in the connective tissue between the capsule and the leaflets. The parenchymal lobules of the pineal gland had no blood vessels. The capillary endothelium is a window (50nm) type, with the basement membrane separated from connective tissue surrounding the blood vessels. Pineal parenchymatous leaflets mainly composed of pineal cells and a small number of glial cells. Pineal somatic cells terminate in the vascular perivascular space; a large number of secretory granules present in the pineal cells protruding clubbing terminal occasionally found in the connective tissue gap; secretory granules diameter of 200 ~ 500nm large-scale membrane pack core particles . Conclusions These ultrastructural features suggest that the efflux form of pineal somatic cell secretory granules may be an overall release rather than exocytosis; secreted granules are more neuropeptides rather than biogenic amines; pineal secretions are more likely to be meridian Tissue information channels are released into cerebrospinal fluid instead of penetrating the capillary wall into the bloodstream.