1)经临床及病理诊断的十六例人生殖道湿疣标本(14例取自宫颈,2例取自外阴)在电镜下显示当人乳头瘤病毒(HPV)感染的早期,鳞状上皮的基底及副基底层明显增生,核大而圆,常染质色丰富并出现多量的“染色质之间颗粒”“染色质周围颗粒”及“核体(nuclear bodies)”,分裂像很多。这是产生乳头状或扁平“疣”的病理基础,在以往文献中未引起足够重视。2)细胞被HPV感染的早、中期,胞质及核内逐渐出现由电子致密度高的均匀基质组成的团块,呈圆或椭圆形,边缘大部清晰。这种致密基质团盐随病变的发展逐渐增大互相融合,形成胞质内核周巨大的基质 1) Clinically and pathologically, 16 specimens of genital warts (14 from the cervix and 2 from the vulva) were examined electron microscopically for the early stage of human papillomavirus (HPV) infection. The base of the squamous epithelium And sub-basal layer was significantly hyperplasia, nuclear large and round, often rich in color and abundance of a large number of “chromatin particles” “chromatin around the particles” and “nuclear bodies”, like a lot of split. This is to produce papillary or flat “warts” pathological basis, in the literature did not pay enough attention. 2) The cells were gradually infected by HPV in early, mid, cytoplasm and nucleus. The clumps formed by homogeneous matrix with high electron density were round or oval, and the edges were mostly clear. This dense matrix of salt with the development of lesions gradually increased mutual integration, the formation of cytoplasmic perinuclear weeks of the matrix