次级淋巴组织趋化因子 (SLC)是体内重要的趋化因子 ,高表达于次级淋巴组织 ,通过与细胞表面受体结合 ,趋化并活化T淋巴细胞、天然杀伤细胞和树突状细胞等免疫效应细胞 ,在机体抗感染和抗肿瘤免疫中具有重要的调节作用。现综述SLC的生物学特性 ,并重点阐述SLC的抗肿瘤机制和在肿瘤治疗中的研究进展 Secondary lymphoid tissue chemokines (SLCs) are important chemokines in the body that are highly expressed in the secondary lymphoid tissues and chemotactic and activate T-lymphocytes, natural killer cells and dendritic cells by binding to cell surface receptors Such as immune effector cells, in the body anti-infection and anti-tumor immunity has an important regulatory role. Now summarize the biological characteristics of SLC, and focus on the anti-tumor mechanism of SLC and research progress in the treatment of cancer