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环丙氟哌酸在健康入和肾衰病人体内的药代动力学迄今已有不少报告。本文研究了肝硬变对环丙氟哌酸药代动力学的影响。试验将受试者分为两组。试验组为7例经活组织检查确诊为肝硬变病人,年龄44-65岁,血清肌酸酐值均在正常范围。对照组为7名健康志愿者,年龄46-68岁,血清肌酸酐及肝功能均正常。受试者口服环丙氟哌酸750mg,12h一次,共5天,试验中定期采集受试者血样及尿样,用HPLC法测定环丙氟哌酸及其代谢物M_1(去乙酰环丙氟哌
There have been many reports of the pharmacokinetics of ciprofloxacin in healthy infants and those with renal failure. This article studies the effects of cirrhosis on the pharmacokinetics of ciprofloxacin. Subjects were divided into two groups. The experimental group was diagnosed as liver cirrhosis by biopsy in 7 patients, aged 44-65 years. Serum creatinine values were in the normal range. The control group of seven healthy volunteers, aged 46-68 years old, serum creatinine and liver function were normal. The subjects received oral ciprofloxacin 750mg, 12h once, a total of 5 days, the subjects regularly collected blood samples and urine samples were measured by HPLC Ciprofloxacin and its metabolites M_1 (deacetyl cyclopropane fluoride Piperazine