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补体系统是固有免疫系统的重要组成部分,同时也是连接固有免疫和适应性免疫系统的重要桥梁.补体系统由30多种蛋白质组成,且其中绝大多数都经过糖基化修饰.近年来对补体系统的研究,不断揭示出补体系统在抗击病原微生物入侵和维持有机体生理稳态过程中发挥着重要作用.然而补体系统需要严格的调控,不论是激活不足、抑或是过度激活都可能引起疾病的发生.本文概述了近年来对于补体系统的激活、调控和功能研究的最新进展,并首次从糖生物学角度对补体系统蛋白质组分的糖链结构及糖链对相应蛋白质功能的影响进行了综述和小结.
Complement system is an important part of the innate immune system, but also an important bridge between innate immunity and adaptive immune system.Complement system consists of more than 30 kinds of proteins, and most of them are glycosylated.In recent years, complement The systematic research has revealed that the complement system plays an important role in fighting the invasion of pathogenic microorganisms and maintaining the physiological homeostasis of the organism, however, the complement system needs strict regulation, which may cause the occurrence of diseases whether under-activated or over-activated This review summarizes the recent advances in the study of activation, regulation and function of complement systems and reviews for the first time the effects of sugar chain structure of protein components in the complement system and the function of sugar chains on the corresponding proteins in terms of glycogen biology. summary.