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目的 :通过对原发性肝癌术中置肝动脉泵皮下埋藏的病人术后泵内注射化疗药的同时注入白介素 2的过程观察对治疗作用的影响。方法 :36例随机分成两组 :一组给予注射化疗药 ,另一组同时给予 IL - 2 ,用药前、三个疗程后分别行流式细胞仪测定淋巴细胞的表型并对化疗的副反应进行对比分析。结果 :用药后联全用药组比单用化疗组外周血 CD3+,CD4+,CD8+,CD5 6 +明显升高 (P<0 .0 5 )。且化疗副反应较小。结论 :IL - 2与化疗联合应用组比单用化疗组具有提高机体免疫机能的作用。且可减轻化疗副反应以提高疗效。
Objective : To observe the effect of injection of interleukin 2 on the treatment of patients with primary hepatocellular carcinoma after intraoperative injection of chemotherapeutic drugs into the subcutaneous tissue of a hepatic artery pump. METHODS: Thirty-six patients were randomly divided into two groups: one group was given chemotherapeutic drugs; the other group was given IL-2 at the same time. Flow cytometry was used to determine the phenotype of lymphocytes and side effects of chemotherapy before and after the three courses of treatment. Conduct comparative analysis. RESULTS: Compared with the chemotherapy alone group, the CD3+, CD4+, CD8+, and CD5 6+ levels in peripheral blood were significantly higher in the combined group after administration (P<0.05). And chemotherapy less side effects. Conclusion : The combination of IL-2 and chemotherapy group has the function of improving the immune function of the body than the chemotherapy alone group. And can reduce chemotherapy side effects to improve efficacy.