论文部分内容阅读
目的探讨急性脑梗死患者血小板功能、凝血与纤溶功能及炎症因子的变化情况。方法采用血凝仪和全自动生化分析仪测定106例急性脑梗死患者APTT、FIB、D-二聚体、hs-CRP、IL-6、TNF-α、PAg T等指标水平,并与100名健康者进行对照。结果急性脑梗死组患者凝血功能中APTT值明显缩短,FIB值和D-二聚体值明显增大,炎症因子中IL-6值、hs-CRP和TNF-α值明显升高,PAg T值增大,与对照组比较均有明显差异(P<0.01)。重度脑梗死组与中度和轻度脑梗死组比较,中度脑梗死组与轻度脑梗死组比较,各项检查值均明显改变(P<0.05)。采用多联指标分析,四项检测指标联合和五联项检测指标联合进行急性脑梗死预测与诊断,其灵敏性(100%,97%)、特异性(98%,100%)、阳性预测值(98%,100%)和阴性预测值(100%,97%)较理想。结论检测APTT值、FIB值、D-二聚体值、IL-6值、hs-CRP、TNF-α值和PAg T值对急性脑梗死的诊断和预后判断有一定的临床意义。
Objective To investigate the changes of platelet function, coagulation and fibrinolytic function and inflammatory cytokines in patients with acute cerebral infarction. Methods The levels of APTT, FIB, D-dimer, hs-CRP, IL-6, TNF-α and PAg T in 106 patients with acute cerebral infarction were measured by coagulation analyzer and automatic biochemical analyzer. Healthy people to control. Results APTT value of coagulation function in patients with acute cerebral infarction was significantly shortened, FIB value and D-dimer value were significantly increased, IL-6, hs-CRP and TNF-α levels in inflammatory cytokines were significantly increased, while PAg T Increase, compared with the control group were significantly different (P <0.01). Severe cerebral infarction group and moderate and mild cerebral infarction group, moderate cerebral infarction group and mild cerebral infarction group, the examination values were significantly changed (P <0.05). The sensitivity, specificity and accuracy of multi-index analysis combined with four detection indexes and five-item detection indexes were used to predict and diagnose acute cerebral infarction. The sensitivity (100%, 97%), specificity (98%, 100% (98%, 100%) and negative predictive value (100%, 97%) is more ideal. Conclusions The detection of APTT, FIB, D-dimer, IL-6, hs-CRP, TNF-α and PAg T have some clinical significance in the diagnosis and prognosis of acute cerebral infarction.