乙胺碘呋酮(A)为一抗心律失常药,在服药过程中常出现甲状腺机能亢进、肺部纤维化、皮疹等毒副作用。这是由于其亲脂性,与在服用过程中在脂肪、骨骼中长期积累有关。A主要经N-去乙酰化代谢,据报道代谢产物去乙酰乙胺碘呋酮(DA)也有活性作用。长期服用A者,A与DA的消除半减期可达30天,并且个体治疗血药浓度差异较大,故测定血浆中A、DA,对于预防积累中毒,调整 Amiodarone (A) is an anti-arrhythmic drug and often presents with side effects such as hyperthyroidism, pulmonary fibrosis and skin rash during medication. This is due to its lipophilicity, which is related to its long-term accumulation in fat and bone during its administration. A is mainly N-deacetylated, and the metabolite deacetoxylamine iodine (DA) is also reported to be active. Long-term use of A, A and DA eliminate half-dead up to 30 days, and the individual treatment of plasma concentrations vary greatly, so the determination of plasma A, DA, for the prevention of accumulation of poisoning, adjustment