论文部分内容阅读
目的比较埃索美拉唑与奥美拉唑治疗胃食管反流病的效果。方法选择青海大学医学院附属医院2011年1月-2013年12月收治的胃食管反流病患者80例,随机分为两组,各40例。观察组给予标准剂量的埃索美拉唑治疗,对照组给予大剂量奥美拉唑治疗,两组均治疗8周。治疗前后观察患者烧心、反酸、胸痛、咽下困难等症状缓解情况,并统计症状积分变化情况。治疗前后采用SF-36健康量表评价患者生活质量变化情况。采用SPSS 19.0统计学软件进行数据处理,计数资料采用百分率表示,组间比较采用χ2检验,计量资料以(xˉ±s)表示,组间比较采用独立样本t检验,组内治疗前后比较采用配对t检验。P<0.05为差异有统计学意义。结果观察组和对照组治疗后总症状积分(5.26±2.43和6.19±2.84)均较治疗前明显降低(17.32±5.04和16.95±5.71),差异均有统计学意义(P<0.05),两组间治疗后差异无统计学意义(P>0.05)。观察组烧心、胸痛缓解率高于对照组(均P<0.05);两组反酸、咽下困难缓解率差异无统计学意义(均P>0.05)。两组治疗后躯体疼痛、总体健康、活力、社会功能、情感职能和精神健康均较治疗前好转(均P<0.05);其中观察组躯体疼痛、活力和社会功能评分明显高于对照组(均P<0.05)。结论相对于大剂量奥美拉唑,常规剂量埃索美拉唑能更有效地缓解胃食管反流患者临床症状,此外其在改善患者生活质量方面有明显优势,值得应用。
Objective To compare the efficacy of esomeprazole and omeprazole in the treatment of gastroesophageal reflux disease. Methods Eighty patients with gastroesophageal reflux disease admitted to Affiliated Hospital of Qinghai University School of Medicine from January 2011 to December 2013 were randomly divided into two groups of 40 cases each. The observation group was given standard dose of esomeprazole, the control group was given high-dose omeprazole, and both groups were treated for 8 weeks. The patients’ heartburn, acid reflux, chest pain, swallowing difficulties and other symptoms were observed before and after treatment, and the change of symptom score was calculated. Before and after treatment with SF-36 health scale evaluation of patients with changes in quality of life. Data were processed by using SPSS 19.0 statistical software. The count data were expressed as a percentage. Chi-square test was used to compare the data between the groups. The measurement data were expressed as (xˉ ± s). The independent samples t-test was used to compare the groups. Paired t test. P <0.05 for the difference was statistically significant. Results The total symptom scores (5.26 ± 2.43 and 6.19 ± 2.84) in observation group and control group were significantly lower than those before treatment (17.32 ± 5.04 and 16.95 ± 5.71, respectively, P <0.05) After treatment there was no significant difference (P> 0.05). The relief rate of heartburn and chest pain in the observation group was higher than that of the control group (all P <0.05). There was no significant difference in the rate of relieving pain between the two groups (all P> 0.05). Body pain, general health, vitality, social function, emotional function and mental health in both groups were better than those before treatment (all P <0.05). The scores of somatic pain, vitality and social function in the observation group were significantly higher than those in the control group P <0.05). Conclusions Compared with high-dose omeprazole, conventional esomeprazole can effectively alleviate the clinical symptoms of patients with gastroesophageal reflux disease. In addition, it has obvious advantages in improving the quality of life of patients and is worthy of application.