作者用淀粉、阿拉伯胶、乙基纤维素、羧甲基纤维素钠和PVP等不同的粘合剂制备新诺明片以比较不同粘合剂的影响。试验结果表明,就颗粒的性质比较,PVP为最佳粘合剂。用PVP粘合剂制备的颗粒其流出速度最佳(每秒3.3g)、休止角最小(18°82′)、细粉的比率低达9.0％,可压性仅为6.5％;淀粉为第二种最佳粘合剂,淀粉浆与其它粘合剂相比,具有良好的粘性,对崩解时间和溶出度的影响较小。对颗粒的可压性和流动性的要求,玉米淀粉比其他来源淀粉更为适用。羧甲基纤维素钠作粘合剂制成的 The authors used different binders such as starch, acacia, ethylcellulose, sodium carboxymethylcellulose, and PVP to prepare a cinobufagin to compare the effects of different binders. The test results show that, compared with the nature of the particles, PVP is the best binder. The pellets prepared with PVP binder had the best outflow rate (3.3 g / sec) with the lowest angle of repose (18 ° 82 ’), the fine powder fraction of 9.0% and the compressibility of only 6.5% The two best binders, starch pastes, have good viscosities compared to other binders with less effect on disintegration time and dissolution. Corn starch is more suitable than starch from other sources for its compressibility and fluidity. Carboxymethyl cellulose sodium as a binder made