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目的:研究高血压病患者脂蛋白脂肪酶(liportein lipase,LPL)S447X基因多态性与认知功能之间的关系。方法:对2008年1月至2008年11月在四川大学华西医院医院门诊就诊的原发性高血压患者190例,收集一般资料,采用国际通用的简易智力状况量表测验认知功能,计算认知评分,用聚合酶链反应-限制性片段长度多态性(PCRRFLP)技术测定LPL S447X基因多态性。同时测定胆固醇、甘油三酯、空腹血糖、空腹胰岛素及餐后2h血糖、餐后2h胰岛素水平。结果:高血压病患者认知功能正常组和认知功能障碍组组间LPLS447X基因的基因型和基因频率差异均无统计学意义(P>0.05),SS和SX频率分别为92.6%、7.4%,S和X等位基因频率分别为96.3%和3.7%。结论:LPL S447X基因多态性可能与高血压认知功能障碍无明显相关性。
Objective: To investigate the relationship between polymorphism of S447X gene and cognitive function in patients with essential hypertension. Methods: From January 2008 to November 2008, 190 patients with essential hypertension in Outpatient Hospital of West China Hospital of Sichuan University were enrolled. General information was collected and the cognitive function was tested by the International Simple Mental State Inventory. The scores of LPL S447X gene polymorphism were determined by polymerase chain reaction-restriction fragment length polymorphism (PCRRFLP). Simultaneous determination of cholesterol, triglycerides, fasting blood glucose, fasting insulin and 2h postprandial blood glucose, 2h postprandial insulin levels. Results: There was no significant difference in the genotypes and gene frequencies of LPLS447X between patients with normal cognitive function and cognitive dysfunction (P> 0.05). The frequencies of SS and SX were 92.6%, 7.4% The frequencies of S and X alleles were 96.3% and 3.7%, respectively. Conclusion: LPL S447X gene polymorphism may not be associated with hypertension cognitive dysfunction.