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我国螨性变态反应的研究开始于1970年代上海第一医学院(现为复旦大学上海医学院)。上海当地的粉尘螨螨种制备的变应原SMU-Df,其过敏活性与国外同种比较,超过许多倍属于最高的,包括美国食品药品管理局参考品、弗吉尼亚大学标准品、丹麦哥本哈根变态反应研究所标准质量品等。SMU-Df经凝胶层析所显示的蛋白峰曲线型与粉尘螨代谢培养基者基本相似,其变应原性也相仿。过敏病例可用皮肤点刺试验、鼻腔激发试验和血清IgE水平测定方法诊断,80%左右的过敏患者呈阳性反应。粉尘螨注射液是我国第一种由卫生主管部门批准生产的商品变应原,用传统的皮下注射免疫治疗,通过季节性脱敏,大多数患者可减轻过敏症状,具有极好的疗效。尘螨特异性免疫治疗具有远期疗效而无严重不良反应。对于粉尘螨粗抗原的改良处方和不同给药途径进行过研究,尤其舌下含服粉尘螨滴剂制备和临床应用从1992年与国外同步开始,对于儿童尤其适用而无年龄限制,疗效极好。螨苗冲击特异性免疫疗法具有快速改善过敏症状且有远期疗效。粉尘螨变应原具有诱导人体免疫调节作用,不论过敏患者或健康人群都产生免疫应答。
The study of mite allergy in China began in the 1970s Shanghai First Medical College (now Shanghai Medical College of Fudan University). The allergen SMU-Df prepared from local dust mite mite species in China has more than many times the allergic activity of the foreign counterparts, including the US Food and Drug Administration’s Reference Standards, the University of Virginia Standards, Copenhagen, Denmark Allergy Institute of standard quality products. SMU-Df by gel chromatography showed peak protein peak curve and dust mite metabolic medium were similar, its allergenicity is also similar. Allergic skin prick test available cases, nasal provocation test and serum IgE levels of diagnosis, about 80% of allergic patients was positive. Dermatophagoides farinae injection is the first commercial product allergen approved by the competent health authority in China. It is immunosuppressed by traditional subcutaneous injection. Through seasonal desensitization, most patients can relieve allergy symptoms and have excellent curative effect. Dust mite-specific immunotherapy has long-term efficacy without serious adverse reactions. The improved prescription and administration routes for the crude antigens of dust mites have been studied. Especially the preparation and clinical application of sublingual dust mite drops began simultaneously with foreign countries in 1992, which is especially suitable for children with no age restriction and has excellent curative effect . Mite vaccine impact-specific immunotherapy has the rapid improvement of allergy symptoms and long-term efficacy. Dust mite allergen has the role of inducing human immune regulation, whether allergic patients or healthy people have an immune response.