对肾综合征出血热（ＨＦＲＳ）沙鼠苗和地鼠苗进行免疫学效果观察。采用ＩＦＡＴ和ＭＣＰＥＮＴ法检测荧光抗体和中和抗体。通过６次采血（即免前、基免后两周，加强免疫前，加强免疫后两周，基免后第三年，基免后第四年）检测抗体，大洼地区沙鼠苗ＩＦＡ抗体阳转率分别为６２％（隐性感染）、１００％、５４９％、１００％、７７４％、７２０％；中和抗体阳转率分别为０、７０４％、０、７３０％、３２３％、３２０％。葫芦岛地区地鼠苗ＩＦＡ抗体阳性率分别为９９％（隐性感染）、１００％、３６４％、１００％、７７１％、８００％；中和抗体阳转率分别为０、５０％、１８％、１００％、５１４％、４４％。结果表明，两型疫苗具有良好的保护性和抗体的持续性。 Immunological effects of hemorrhagic fever with renal syndrome (HFRS) gerbils and hamster seedlings were observed. Fluorescent and neutralizing antibodies were detected using the IFAT and MCPENT methods. The anti-IFA antibodies of Douchou gerbil were detected by 6 times of blood sampling (ie, two weeks before immunization, two days after immunization, two weeks after boosting, three years after immunization, and the fourth year after immunization) The positive rate of positive antibody was 62% (recessive infection), 100%, 549%, 100%, 774%, 720% respectively. The positive rate of neutralizing antibody was 0704% , 0,73  0%, 32  3%, 32  0%. The positive rates of IFA antibody in the hamster seedlings of Huludao were 99% (recessive), 100%, 364%, 100%, 771% and 800% respectively. The positive rate of neutralizing antibody 0, 50%, 18%, 100%, 514%, 44%. The results showed that the two types of vaccines have good protection and antibody persistence.