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目的探讨人参皂苷Rbl(Ginsenoside Rb1,GSRb1)对大鼠局灶性脑缺血白质重塑的影响。方法大鼠随机分为假手术组、溶媒处理组和人参皂苷Rbl处理组,采用线栓法建立大鼠大脑中动脉缺血再灌注(middle cerebral artery occlusion/reperfusion,MCAO/R)损伤模型,用LFB染色观察大鼠胼胝体和内囊的髓鞘变化,用免疫组化染色法检测缺血侧胼胝体GFAP和APP的表达以评估星形胶质细胞和轴突的改变。结果缺血2 h再灌72 h后,溶媒处理组胼胝体和内囊有明显的髓鞘紊乱、脱失,胼胝体GFAP和APP表达显著增加。与溶媒处理组相比,GSRb1处理组髓鞘脱失有明显改善(P<0.01,P<0.05)且胼胝体GFAP和APP表达显著减少(P<0.05)。结论 GSRb1可能促进大鼠局灶性脑缺血后脑白质重塑。
Objective To investigate the effects of ginsenoside Rb1 (GSRb1) on focal cerebral ischemia and remodeling in rats. Methods Rats were randomly divided into sham-operation group, vehicle-treated group and ginsenoside Rb1-treated group. The middle cerebral artery occlusion / reperfusion (MCAO / R) The changes of myelin in the corpus callosum and the internal capsule were observed by LFB staining. The expressions of GFAP and APP in the ischemic corpus callosum were detected by immunohistochemistry to evaluate the changes of astrocytes and axons. Results After reperfusion for 72 h at 2 h of ischemia, the myelin sheaths and internal capsule of the vehicle-treated group had obvious myelin sheath disorganization and loss, and the expression of GFAP and APP in the corpus callosum increased significantly. Compared with the vehicle-treated group, the GSRb1-treated group showed a significant improvement in myelinolysis (P <0.01, P <0.05) and GFAP and APP expression in the corpus callosum significantly decreased (P <0.05). Conclusion GSRb1 may promote the white matter remodeling after focal cerebral ischemia in rats.