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为探讨国产硒酵母硒在低硒人体的生物利用率,将克山病病区52例青少年随机分成3组,分别每日口服硒酵母硒200μg、亚硒酸钠硒200μg和普通酵母片共12周。于服硒前、服硒4和8周以及停硒8周时,采血测定硒含量和谷胱甘肽过氧化物酶(GSH_(PX))活性。结果表明:①硒酵母硒在血浆和红细胞积蓄明显高于亚硒酸钠;②硒酵母硒在提高和维持血小板GSH_(PX)活性上优于亚硒酸钠;③以红细胞和血浆硒积蓄为指标时,硒酵母硒的相对生物利用率分别为556%和178%;以血小板和血浆GSH_(PX)活性为指标时,硒酵母硒的相对生物利用率分别为158%和116%。说明克山病病区低硒青少年对硒酵母硒的生物利用率高于亚硒酸钠。
In order to investigate the bioavailability of domestic selenium yeast in low selenium, 52 adolescents in Keshan disease area were randomly divided into three groups. The selenium yeast selenium 200μg, selenium 200μg selenium and common yeast week. Serum selenium content and glutathione peroxidase (GSH PX) activity were determined by taking selenium for 4 and 8 weeks before taking selenium and 8 weeks after stopping selenium. The results showed that: ① Selenium yeast selenium in plasma and erythrocyte accumulation was significantly higher than sodium selenite; ② Selenium yeast selenium was superior to sodium selenite in enhancing and maintaining platelet GSH PX activity; ③ Selenium accumulation in erythrocytes and plasma was The relative bioavailability of selenium yeast selenium was 556% and 178%, respectively. The relative bioavailability of selenium yeast selenium was 158% and 116%, respectively, based on platelet and plasma GSH PX activity. It shows that the bioavailability of selenium in selenium yeast is lower than that of sodium selenite in low-selenium adolescents in Keshan disease area.