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上皮-间质转化与上皮性卵巢肿瘤的侵袭和转移密切相关,氧化应激对疾病的发生、发展有重要影响。活性氧作为氧化应激过程中的重要产物,在卵巢癌细胞上皮-间质转化中通过对多种因子的调节参与卵巢癌细胞增殖分化、黏附和迁移等,在卵巢癌的诊断、治疗及预后中有重要作用。本文就活性氧对卵巢癌上皮-间质转化作用的研究进展作一综述。
Epithelial-interstitial transformation is closely related to the invasion and metastasis of epithelial ovarian tumors, and oxidative stress has a significant impact on the occurrence and development of the disease. As an important product of oxidative stress, reactive oxygen species (ROS) are involved in the proliferation, differentiation, adhesion and migration of ovarian cancer cells through the regulation of many factors in the epithelial-mesenchymal transition of ovarian cancer cells. In the diagnosis, treatment and prognosis of ovarian cancer In an important role. This review summarizes the research progress of reactive oxygen species in the epithelial-mesenchymal transition of ovarian cancer.