论文部分内容阅读
目的分析干扰素治疗慢性丙型肝炎对甲状腺功能的影响。方法收集2014年1月-2016年12月收治的慢性丙型肝炎轻度、中度及早期肝纤维化患者40例作为研究组,选取同期健康体检者30例作为对照组,采用化学发光免疫分析法检测研究组干扰素治疗前、中、后甲状腺激素及抗体水平,并与对照组比较。结果研究组出现甲状腺疾病8例(20.0%),其中甲亢5例,甲减3例。研究组治疗前血清甲状腺球蛋白抗体(TGAb)和抗甲状腺过氧化物酶抗体(TPOAb)的阳性率分别为15.0%(6/40)和12.5%(5/40),对照组TGAb和TPOAb的阳性率分别为0和6.7%(2/30),2组TGAb和TPOAb阳性率比较差异均有统计学意义(P<0.05);且研究组治疗后TGAb和TPOAb的阳性率均低于治疗前(P<0.05)。研究组治疗前甲状腺激素水平均在正常范围,但游离三碘甲状原氨酸(FT3)、游离甲状腺素(FT4)均显著低于对照组(P<0.05)。研究组治疗后FT3、FT4均显著升高,与治疗前比较差异均有统计学意义(P<0.05);研究组治疗过程中TSH较治疗前有明显增高(P<0.05),随着治疗的进展TSH逐渐恢复正常。结论慢性丙型肝炎患者可存在甲状腺功能异常,干扰素治疗中可出现一过性甲状腺激素代谢紊乱,其中TSH的检测更灵敏,TGAb、TPOAb可作为干扰素(IFN)治疗中甲状腺疾病发生发展的预测因素。
Objective To analyze the effect of interferon on thyroid function in chronic hepatitis C patients. Methods Forty patients with mild, moderate and early hepatic fibrosis who were admitted to our hospital from January 2014 to December 2016 were enrolled as study group and 30 healthy subjects were enrolled as control group. Chemiluminescence immunoassay France test group interferon treatment before, during and after thyroid hormone and antibody levels, and compared with the control group. Results There were 8 cases (20.0%) of thyroid diseases in the study group, including 5 cases of hyperthyroidism and 3 cases of hypothyroidism. The positive rates of serum thyroglobulin antibody (TGAb) and anti-thyroid peroxidase antibody (TPOAb) in the study group before treatment were 15.0% (6/40) and 12.5% (5/40), respectively. The TGAb and TPOAb The positive rates of TGAb and TPOAb in the two groups were statistically significant (P <0.05). The positive rates of TGAb and TPOAb in the study group were lower than those before treatment (P <0.05). The levels of thyroid hormones in the study group before treatment were in the normal range, but the free triiodothyronine (FT3) and free thyroxine (FT4) were significantly lower than those in the control group (P <0.05). The FT3 and FT4 in the study group were significantly higher than those before treatment (P <0.05). The TSH in the study group was significantly higher than that before treatment (P <0.05) Progress TSH gradually returned to normal. Conclusions Thyroid dysfunction may exist in patients with chronic hepatitis C, and transient thyroid hormone metabolism disorder may occur in the treatment of interferon. The detection of TSH is more sensitive and TGAb and TPOAb may be used as the development of thyroid diseases in the treatment of interferon (IFN). Predictors.