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目的 探讨预防婴儿维生素K缺乏性出血症的有效措施。方法 婴儿出生后即口服维生素K_1,每10天1次,每次2.5mg,共 10次,并采脐带血、1个月和 2个月静脉血,统一检测。结果 群体干预研究服药组维生素K缺乏性出血症发生率明显低于对照组(P<0.01)。小样本的实验室观察结果显示了口服组1个月和2个月静脉血维生素K缺乏诱导蛋白(PIVKA-Ⅱ)已经完全转阴。结论 婴儿口服维生素K_1能有效地预防典型及晚发性维生素K缺乏性出血症。
Objective To explore the effective measures to prevent infantile vitamin K deficiency bleeding. Methods Infants were born after oral vitamin K 1, once every 10 days, each 2.5mg, a total of 10 times, and cord blood collection, 1 month and 2 months of venous blood, a unified test. Results The results of population intervention study showed that the incidence of vitamin K deficiency hemorrhagic disease in the medication group was significantly lower than that in the control group (P <0.01). Laboratory observations in small samples showed that the intravenous vitamin K deficiency-inducing protein (PIVKA-II) was completely negative at 1 month and 2 months in the oral group. Conclusion Infant oral vitamin K 1 can effectively prevent typical and late onset vitamin K deficiency haemorrhage.