在诱导细胞凋亡过程中，许多细胞外刺激常共用一段相同的信号转导路径，可称之为凋亡的基本信号通路。ＴＮＦ受体家族如ＴＮＦ受体及Ｆａｓ受体在与相应的配体结合后，通过蛋白死亡区的相互作用，激活ＩＣＥ蛋白酶家族；活化的蛋白酶引起多种底物如核酸酶抑制剂、细胞骨架蛋白等的降解，导致细胞出现凋亡的生化及形态学改变。 During the induction of apoptosis, many extracellular stimuli often share the same signal transduction pathway, which can be called the basic signaling pathway of apoptosis. The TNF receptor family, such as the TNF receptor and the Fas receptor, activate the ICE protease family upon binding to the corresponding ligand through the interaction of the protein dead regions; the activated protease causes a variety of substrates such as nuclease inhibitors, cytoskeleton Protein degradation, leading to cell apoptosis and biochemical and morphological changes.