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目的对比分析维吾尔族与汉族肾移植术后患者不同时期他克莫司全血谷浓度特征,为他克莫司的临床个体化合理使用提供依据。方法应用Emit 2000法测定21例维吾尔族与25例汉族肾移植术后患者共1 142例次他克莫司全血谷浓度值,按族别、术后时间分组并进行统计分析。结果他克莫司全血谷浓度平均值在术后≤1、1～3、4～6、7～12及>12个月时,在维吾尔族中为(13.49±4.16)、(11.75±3.87)、(8.09±2.19)、(7.17±3.41)及(5.74±2.93)μg·L~(-1),在汉族中为(11.95±3.32)、(10.66±3.33)、(8.09±2.19)、(6.31±2.43)及(4.91±2.15)μg·L~(-1)。维吾尔族肾移植术后患者在不同时期内他克莫司平均谷浓度值与汉族比较差异均具有统计学意义(P<0.05)。结论维吾尔族肾移植术后患者他克莫司全血谷浓度值高于汉族肾移植术后患者。
Objective To compare and analyze the characteristics of tacrolimus whole blood trough concentration in Uygur and Han patients after kidney transplantation at different periods, and provide the basis for the individualized rational use of tacrolimus. Methods Emit 2000 method was used to determine the trough concentrations of tacrolimus in 21 142 Uighurs and 25 Han patients after kidney transplantation. The tacrolimus whole blood trough concentrations were determined by ethnicity and postoperative time and analyzed statistically. Results The mean tacrolimus concentration in the whole blood was (13.49 ± 4.16) and (11.75 ± 3.87) in the Uygur nationality at ≤1, 1-3, 4-6, 7-12, and 12 months after operation ), (8.09 ± 2.19), (7.17 ± 3.41) and (5.74 ± 2.93) μg · L -1 in Han nationality respectively, and were 11.95 ± 3.32, 10.66 ± 3.33 and 8.09 ± 2.19 respectively in Han nationality, (6.31 ± 2.43) and (4.91 ± 2.15) μg · L -1, respectively. The mean tacrolimus trough concentrations in Uighur kidney transplant patients at different periods were significantly different from those in Han (P <0.05). Conclusion The tacrolimus whole blood trough concentration in Uighur kidney transplant patients is higher than that in Han patients after kidney transplantation.