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17例证实为曲菌感染的患者,其中急性非淋巴细胞性白血病12例,急性淋巴细胞性白血病2例,淋巴网细胞瘤Ⅳ—B期伴有骨髓受侵犯1例,淋巴瘤伴有白血病及骨髓受累1例,肺部广泛播散性未分化小细胞癌伴有弥漫性骨髓受累1例。全部患者均有严重中性粒细胞减少(绝对数<500/立方毫米)至少7天,全部患者亦曾经胃肠外途径接受广谱抗菌素至少7天。早期诊断(发现肺部浸润72小时内)及早期二性霉素B治疗(96小时内)者6例。其中3例曲菌感染的体征及症状完全消失,血癌完全或部份缓解,长期存活。曲菌病体征及症状消失较周围血粒细胞数升高
Of the 17 patients with confirmed aspergillosis, 12 were acute non-lymphocytic leukemia, 2 were acute lymphocytic leukemia, 1 was associated with bone marrow involvement in stage IV-B of lymphoblastoma and 1 was associated with lymphoma with leukemia and 1 case of bone marrow involvement, 1 case of extensive disseminated undifferentiated small cell lung cancer with diffuse bone marrow involvement. All patients had severe neutropenia (absolute number <500 per cubic millimeter) for at least 7 days and all patients had also been given parenteral routes of broad spectrum antibiotics for at least 7 days. Early diagnosis (found within 72 hours of lung infiltration) and early amphotericin B treatment (96 hours) in 6 cases. Three cases of signs and symptoms of aspergillosis completely disappeared, blood cancer completely or partially relieved, long-term survival. Aspergillosis signs and symptoms disappeared than the surrounding blood cells increased